我看到其他答案中缺少两件事:
- 
canvas.toBlob(如果可用)比 更高性能,并且还具有异步性。canvas.toDataURL
- 文件 -> 图像 -> 画布 -> 文件转换丢失 EXIF 数据;特别是,有关图像旋转的数据通常由现代手机/平板电脑设置。
以下脚本处理这两点:
// From https://developer.mozilla.org/en-US/docs/Web/API/HTMLCanvasElement/toBlob, needed for Safari:
if (!HTMLCanvasElement.prototype.toBlob) {
    Object.defineProperty(HTMLCanvasElement.prototype, 'toBlob', {
        value: function(callback, type, quality) {
            var binStr = atob(this.toDataURL(type, quality).split(',')[1]),
                len = binStr.length,
                arr = new Uint8Array(len);
            for (var i = 0; i < len; i++) {
                arr[i] = binStr.charCodeAt(i);
            }
            callback(new Blob([arr], {type: type || 'image/png'}));
        }
    });
}
window.URL = window.URL || window.webkitURL;
// Modified from https://stackoverflow.com/a/32490603, cc by-sa 3.0
// -2 = not jpeg, -1 = no data, 1..8 = orientations
function getExifOrientation(file, callback) {
    // Suggestion from http://code.flickr.net/2012/06/01/parsing-exif-client-side-using-javascript-2/:
    if (file.slice) {
        file = file.slice(0, 131072);
    } else if (file.webkitSlice) {
        file = file.webkitSlice(0, 131072);
    }
    var reader = new FileReader();
    reader.onload = function(e) {
        var view = new DataView(e.target.result);
        if (view.getUint16(0, false) != 0xFFD8) {
            callback(-2);
            return;
        }
        var length = view.byteLength, offset = 2;
        while (offset < length) {
            var marker = view.getUint16(offset, false);
            offset += 2;
            if (marker == 0xFFE1) {
                if (view.getUint32(offset += 2, false) != 0x45786966) {
                    callback(-1);
                    return;
                }
                var little = view.getUint16(offset += 6, false) == 0x4949;
                offset += view.getUint32(offset + 4, little);
                var tags = view.getUint16(offset, little);
                offset += 2;
                for (var i = 0; i < tags; i++)
                    if (view.getUint16(offset + (i * 12), little) == 0x0112) {
                        callback(view.getUint16(offset + (i * 12) + 8, little));
                        return;
                    }
            }
            else if ((marker & 0xFF00) != 0xFF00) break;
            else offset += view.getUint16(offset, false);
        }
        callback(-1);
    };
    reader.readAsArrayBuffer(file);
}
// Derived from https://stackoverflow.com/a/40867559, cc by-sa
function imgToCanvasWithOrientation(img, rawWidth, rawHeight, orientation) {
    var canvas = document.createElement('canvas');
    if (orientation > 4) {
        canvas.width = rawHeight;
        canvas.height = rawWidth;
    } else {
        canvas.width = rawWidth;
        canvas.height = rawHeight;
    }
    if (orientation > 1) {
        console.log("EXIF orientation = " + orientation + ", rotating picture");
    }
    var ctx = canvas.getContext('2d');
    switch (orientation) {
        case 2: ctx.transform(-1, 0, 0, 1, rawWidth, 0); break;
        case 3: ctx.transform(-1, 0, 0, -1, rawWidth, rawHeight); break;
        case 4: ctx.transform(1, 0, 0, -1, 0, rawHeight); break;
        case 5: ctx.transform(0, 1, 1, 0, 0, 0); break;
        case 6: ctx.transform(0, 1, -1, 0, rawHeight, 0); break;
        case 7: ctx.transform(0, -1, -1, 0, rawHeight, rawWidth); break;
        case 8: ctx.transform(0, -1, 1, 0, 0, rawWidth); break;
    }
    ctx.drawImage(img, 0, 0, rawWidth, rawHeight);
    return canvas;
}
function reduceFileSize(file, acceptFileSize, maxWidth, maxHeight, quality, callback) {
    if (file.size <= acceptFileSize) {
        callback(file);
        return;
    }
    var img = new Image();
    img.onerror = function() {
        URL.revokeObjectURL(this.src);
        callback(file);
    };
    img.onload = function() {
        URL.revokeObjectURL(this.src);
        getExifOrientation(file, function(orientation) {
            var w = img.width, h = img.height;
            var scale = (orientation > 4 ?
                Math.min(maxHeight / w, maxWidth / h, 1) :
                Math.min(maxWidth / w, maxHeight / h, 1));
            h = Math.round(h * scale);
            w = Math.round(w * scale);
            var canvas = imgToCanvasWithOrientation(img, w, h, orientation);
            canvas.toBlob(function(blob) {
                console.log("Resized image to " + w + "x" + h + ", " + (blob.size >> 10) + "kB");
                callback(blob);
            }, 'image/jpeg', quality);
        });
    };
    img.src = URL.createObjectURL(file);
}
用法示例:
inputfile.onchange = function() {
    // If file size > 500kB, resize such that width <= 1000, quality = 0.9
    reduceFileSize(this.files[0], 500*1024, 1000, Infinity, 0.9, blob => {
        let body = new FormData();
        body.set('file', blob, blob.name || "file.jpg");
        fetch('/upload-image', {method: 'POST', body}).then(...);
    });
};